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Clinical Trial
. 2007 Nov;92(11):1579-80.
doi: 10.3324/haematol.12033.

Long-term molecular responses to imatinib in patients with chronic myeloid leukemia: comparison between complete cytogenetic responders treated in early and in late chronic phase

Francesca Palandri, Ilaria Iacobucci, Fabrizio Quarantelli, Fausto Castagnetti, Daniela Cilloni, Michele Baccarani; GIMEMA Working Party on CML
Free article
Clinical Trial

Long-term molecular responses to imatinib in patients with chronic myeloid leukemia: comparison between complete cytogenetic responders treated in early and in late chronic phase

Francesca Palandri et al. Haematologica. 2007 Nov.
Free article

Abstract

CML patients who obtain a complete cytogenetic response (CCgR) may harbor different degrees of molecular disease, which are associated with different progression-free survival. We have compared the pattern and the magnitude of the molecular response (MolR) of 54 early chronic phase (ECP) and of 115 late CP patients who achieved a stable CCgR with IM 400 mg/daily. ECP patients obtained earlier, higher and more sustained MMolR.

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