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. 2007 Nov 30;21(18):2546-9.
doi: 10.1097/QAD.0b013e3282f2a94f.

Impact of chronic hepatitis C and/or D on liver fibrosis severity in patients co-infected with HIV and hepatitis B virus

Karine Lacombe  1 , Anders Boyd, Moise Desvarieux, Lawrence Serfaty, Philippe Bonnord, Joel Gozlan, Jean-Michel Molina, Patrick Miailhes, Caroline Lascoux-Combe, Elyanne Gault, Pierre-Marie Girard
Affiliations

Impact of chronic hepatitis C and/or D on liver fibrosis severity in patients co-infected with HIV and hepatitis B virus

Karine Lacombe et al. AIDS. .

Abstract

The histological study on the reciprocal influence of chronic hepatitis C (HCV) and/or delta (HDV) on liver damage in a cohort of 134 HIV-HBV co-infected patients concluded on a significant association between HDV co-infection (noted in 13 patients) and Metavir F3-F4 liver fibrosis score [odds ratio (OR) = 7.08, 95% confidence interval (CI) = 1.06-47.28 for HBV-HDV, OR = 10.02, 95% CI = 1.03-97.42 for HBV-HCV-HDV, compared to OR = 1.76, 95% CI = 0.50-6.17 for HBV alone]. Co-treatment of other multiple viral hepatitis infections should also be taken into consideration, especially in the case of chronic HDV.

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