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. 2007 Dec;39(12):1437-9.
doi: 10.1038/ng.2007.23. Epub 2007 Nov 18.

Cystatin C modulates cerebral beta-amyloidosis

Stephan A Kaeser  1 , Martin C Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb, Mathias Jucker
Affiliations

Cystatin C modulates cerebral beta-amyloidosis

Stephan A Kaeser et al. Nat Genet. 2007 Dec.

Abstract

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

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