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. 2007 Aug-Nov;11(3-4):115-8.
doi: 10.1007/s11030-007-9065-5. Epub 2007 Nov 20.

Natural macrocyclic molecules have a possible limited structural diversity

Aaron T Frank  1 , Nicola S Farina, Nahed Sawwan, Orrette R Wauchope, Mo Qi, Edyta M Brzostowska, Wang Chan, Frank W Grasso, Paul Haberfield, Alexander Greer
Affiliations

Natural macrocyclic molecules have a possible limited structural diversity

Aaron T Frank et al. Mol Divers. 2007 Aug-Nov.

Abstract

This paper examines ring size patterns of natural product macrocycles. Evidence is presented that natural macrocycles containing 14-, 16-, and 18-membered rings are of frequent occurrence based on a data mining study. The results raise a question about the limited diversity of macrocycle ring sizes and the nature of the constraints that may cause them. The data suggest that the preference bears no relationship to the odd-even frequency in natural fatty acids. The trends reported here, along with those reported previously (Wessjohann et al. (2005) Mol Divers 9:171), may be generalized to better understand the possible structure preferences of natural macrocycles.

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