Review
doi: 10.1016/j.immuni.2007.11.002.
CD4 and CD8: hogging all the Lck
Affiliations
- PMID: 18031691
- DOI: 10.1016/j.immuni.2007.11.002
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Review
CD4 and CD8: hogging all the Lck
Immunity.
2007 Nov.
Free article
Abstract
Specificity of T cell receptors (TCRs) to major histocompatibility complex (MHC) might be intrinsic or imposed by thymic selection. Van Laethem et al. (2007) propose that the sequestration of the kinase Lck by coreceptors prevents the selection of non-MHC-reactive TCRs.
Comment on
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Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.Immunity. 2007 Nov;27(5):735-50. doi: 10.1016/j.immuni.2007.10.007. Immunity. 2007. PMID: 18023370
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