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. 2008 Jan;19(1):135-40.
doi: 10.1681/ASN.2007030308. Epub 2007 Nov 21.

Chronic kidney disease increases risk for venous thromboembolism

Keattiyoat Wattanakit  1 , Mary Cushman, Catherine Stehman-Breen, Susan R Heckbert, Aaron R Folsom
Affiliations

Chronic kidney disease increases risk for venous thromboembolism

Keattiyoat Wattanakit et al. J Am Soc Nephrol. 2008 Jan.

Abstract

Chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease morbidity and mortality, but its association with incident venous thromboembolism (VTE) in non-dialysis-dependent patients has not been evaluated in a community-based population. With the use of data from the Longitudinal Investigation of Thromboembolism Etiology (LITE) study, 19,073 middle-aged and elderly adults were categorized on the basis of estimated GFR, and cystatin C (available in 4734 participants) was divided into quintiles. During a mean follow-up time of 11.8 yr, 413 participants developed VTE. Compared with participants with normal kidney function, relative risk for VTE was 1.28 (95% confidence interval [CI] 1.02 to 1.59) for those with mildly decreased kidney function and 2.09 (95% CI 1.47 to 2.96) for those with stage 3/4 CKD, when adjusted for age, gender, race, and center. After additional adjustment for cardiovascular disease risk factors, an increased risk for VTE was still observed in participants with stage 3/4 CKD, with a multivariable adjusted relative risk of 1.71 (95% CI 1.18 to 2.49). There was no significant association between cystatin C and VTE. In conclusion, middle-aged and elderly patients with CKD (stages 3 through 4) are at increased risk for incident VTE, suggesting that VTE prophylaxis may be particularly important in this population.

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Figures

Figure 1.
Figure 1.
Spline regression of predicted RR of incident VTE in relation to eGFR: LITE.
See this image and copyright information in PMC

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