TDP-43 immunoreactivity in neurodegenerative disorders: disease versus mechanism specificity

Affiliations

Review

Dennis W Dickson. Acta Neuropathol. 2008 Jan.

. 2008 Jan;115(1):147-9.

doi: 10.1007/s00401-007-0323-5. Epub 2007 Nov 23.

¹ Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. dickson.dennis@mayo.edu

No abstract available

Comment on

Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Geser F, et al. Acta Neuropathol. 2008 Jan;115(1):133-45. doi: 10.1007/s00401-007-0257-y. Epub 2007 Aug 23. Acta Neuropathol. 2008. PMID: 17713769
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia.
Zhang H, Tan CF, Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K. Zhang H, et al. Acta Neuropathol. 2008 Jan;115(1):115-22. doi: 10.1007/s00401-007-0285-7. Epub 2007 Sep 5. Acta Neuropathol. 2008. PMID: 17786458
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VM, Trojanowski JQ. Brandmeir NJ, et al. Acta Neuropathol. 2008 Jan;115(1):123-31. doi: 10.1007/s00401-007-0315-5. Epub 2007 Nov 15. Acta Neuropathol. 2008. PMID: 18004574

1. Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer’s disease. Ann Neurol. 2007;61:435–445. - PMC - PubMed
1. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602–611. - PubMed
1. Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VM-Y, Trojanowski JQ. Severe subcortical TDP-43 pathology in sporadic frontotemporal degeneration with motor neuron disease. Acta Neuropathol (Berl) 2008 - PubMed
1. Dickson DW, Josephs KA, Amador-Ortiz C. TDP-43 in differential diagnosis of motor neuron disorders. Acta Neuropathol (Berl) 2007;114:71–79. - PubMed
1. Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol. 2007;171:513–524. - PMC - PubMed