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Review
. 2008 Apr;19(2):204-11.
doi: 10.1016/j.semcdb.2007.10.008. Epub 2007 Oct 22.

Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics

L Aghajanova  1 , A E Hamilton, L C Giudice
Affiliations
Review

Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics

L Aghajanova et al. Semin Cell Dev Biol. 2008 Apr.

Abstract

Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.

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Figures

Figure 1
Figure 1
Distribution of changes in gene expression among different functional classes. A – results from Kao et al., 2002; B – Riesewijk et al., 2003; C - Carson et al., 2002; D –Borthwick et al., 2003; E – Mirkin et al., 2005.
Figure 2
Figure 2. Model of events in early human implantation
LIF- leukemia inhibitory factor; N-Ac6-ST - N-acetylglucosamine-6-O-sulfotransferase; CPE receptor - Clostridium perfringens enterotoxin receptor; IDO - Indoleamine 2,3-dioxygenase; IL-15 – interleukin 15.
See this image and copyright information in PMC

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