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Review
. 2007 Dec:31 Suppl 3:S7-9.
doi: 10.1016/S0145-2126(07)70460-5.

Improving clinical outcome in patients with myelodysplastic syndrome and iron overload using iron chelation therapy

Heather A Leitch  1
Affiliations
Review

Improving clinical outcome in patients with myelodysplastic syndrome and iron overload using iron chelation therapy

Heather A Leitch. Leuk Res. 2007 Dec.

Abstract

Until recently, little information on the benefits of iron chelation therapy (ICT) in patients with myelodysplastic syndrome (MDS) and iron overload was known. A recent retrospective study showed improved survival in transfusion-dependent patients with MDS (Low or Intermediate-1 risk IPSS) receiving ICT, compared with those not receiving ICT; median overall survival was not reached at 160 months versus 40 months, respectively. Significantly more patients receiving ICT survived to 4 years (80% versus 44%; p < 0.03), suggesting that MDS patients with iron overload might benefit from ICT. Prospective studies to confirm the benefit of ICT in MDS are warranted.

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