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Randomized Controlled Trial
. 2008 Feb;28(2):152-6.
doi: 10.1111/j.1468-2982.2007.01488.x. Epub 2007 Nov 26.

Prednisone vs. placebo in withdrawal therapy following medication overuse headache

L Pageler  1 , Z Katsarava, H C Diener, V Limmroth
Affiliations
Randomized Controlled Trial

Prednisone vs. placebo in withdrawal therapy following medication overuse headache

L Pageler et al. Cephalalgia. 2008 Feb.

Abstract

This proof-of-concept study evaluated the efficacy of prednisone for the treatment of withdrawal symptoms in patients with medication overuse headache (MOH) in a randomized, placebo-controlled, double-blind design. Twenty patients were randomized and underwent in-patient withdrawal therapy. The total number of hours with severe or moderate headache within the first 72 and 120 h was significantly lower in the prednisone group. The results show that prednisone might be effective in the treatment of medication withdrawal headache.

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