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Meta-Analysis
. 2007 Dec;24(12):1473-7.
doi: 10.1111/j.1464-5491.2007.02297.x.

No evidence of association of the PDCD1 gene with Type 1 diabetes

Affiliations
Meta-Analysis

No evidence of association of the PDCD1 gene with Type 1 diabetes

S Asad et al. Diabet Med. 2007 Dec.

Erratum in

  • Diabet Med. 2008 Feb;25(2):243. Fawwaz, S [corrected to Asad, S]

Abstract

Aims: To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM.

Methods: Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738.

Results: We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association.

Conclusions: We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.

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