No evidence of association of the PDCD1 gene with Type 1 diabetes
- PMID: 18042085
- DOI: 10.1111/j.1464-5491.2007.02297.x
No evidence of association of the PDCD1 gene with Type 1 diabetes
Erratum in
- Diabet Med. 2008 Feb;25(2):243. Fawwaz, S [corrected to Asad, S]
Abstract
Aims: To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM.
Methods: Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738.
Results: We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association.
Conclusions: We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.
Similar articles
-
Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus.Eur J Hum Genet. 2007 Mar;15(3):336-41. doi: 10.1038/sj.ejhg.5201767. Epub 2007 Jan 17. Eur J Hum Genet. 2007. PMID: 17228327
-
[The analysis on single nucleotide polymorphism of PDCD1 and systemic lupus erythematous susceptibility among Han indigenous in Chinese population].Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Sep;26(9):698-701. Zhonghua Liu Xing Bing Xue Za Zhi. 2005. PMID: 16471222 Chinese.
-
Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus.Metabolism. 2007 Jul;56(7):905-9. doi: 10.1016/j.metabol.2007.01.021. Metabolism. 2007. PMID: 17570250
-
No association of CTLA-4 polymorphisms with susceptibility to Behçet disease.Br J Ophthalmol. 2009 Oct;93(10):1378-81. doi: 10.1136/bjo.2008.156919. Epub 2009 Jun 30. Br J Ophthalmol. 2009. PMID: 19570770 Review.
-
The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.Ann N Y Acad Sci. 2006 Oct;1079:47-50. doi: 10.1196/annals.1375.007. Ann N Y Acad Sci. 2006. PMID: 17130531 Review.
Cited by
-
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.Clin Exp Immunol. 2015 Jun;180(3):452-7. doi: 10.1111/cei.12603. Clin Exp Immunol. 2015. PMID: 25682896 Free PMC article.
-
Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.PLoS One. 2011;6(10):e25345. doi: 10.1371/journal.pone.0025345. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22039410 Free PMC article.
-
The Role of Programmed Death-1 in Type 1 Diabetes.Curr Diab Rep. 2021 May 6;21(6):20. doi: 10.1007/s11892-021-01384-6. Curr Diab Rep. 2021. PMID: 33956235 Free PMC article. Review.
-
Meta-analysis of genetic polymorphisms in programmed cell death 1. Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility.Z Rheumatol. 2015 Apr;74(3):230-9. doi: 10.1007/s00393-014-1415-y. Z Rheumatol. 2015. PMID: 24942602 Review.
-
Programmed cell death 1 gene polymorphisms is associated with ankylosing spondylitis in Chinese Han population.Rheumatol Int. 2011 Feb;31(2):209-13. doi: 10.1007/s00296-009-1264-1. Epub 2009 Dec 12. Rheumatol Int. 2011. PMID: 20012629
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical