Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 May;38(5):465-73.
doi: 10.1111/j.1872-034X.2007.00299.x. Epub 2007 Nov 27.

Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry

Elizabeth M Lehman  1 , Amr S Soliman, Kadry Ismail, Ahmed Hablas, Ibrahim A Seifeldin, Mohamed Ramadan, Hesham El-Hamzawy, Christiana S Shoushtari, Mark L Wilson
Affiliations

Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry

Elizabeth M Lehman et al. Hepatol Res. 2008 May.

Abstract

Aim: Hepatocellular carcinoma (HCC) is increasing worldwide, and is frequently attributed to rising rates of hepatitis C virus infection and interactions between viral and environmental risk factors. Because of Egypt's unique risk factor profile, we analyzed data from the Gharbiah Population-Based Cancer Registry for the period 1999-2003 to characterize demographic and geographic patterns of cases in this province.

Methods: We calculated age- and sex-specific and age- and sex-standardized HCC incidence rates for the eight districts in Gharbiah. We also compared rates from Gharbiah with the USA (US Surveillance Epidemiology and End RESULTS [SEER] database).

Results: The analysis revealed a higher incidence in males than in females, significant geographic variations among districts, and a higher incidence in Gharbiah than that reported by SEER.

Conclusion: The findings of this study document the heterogeneous distribution of HCC at regional and international levels. This population-based registry offers the opportunity for careful representative studies of various etiologies, particularly infectious and/or environmental factors that may contribute to risk.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Northern Egypt (Nile Delta), Gharbiah Province, and its eight districts. (Map: http://www.meccegypt.org).
Figure 2
Figure 2
Mean age-adjusted incidence rates for hepatocellular carcinoma in the eight districts of Gharbiah (1999–2003), standardized to the world million (Parkin et al. 1997). (Map: http://www.meccegypt.org).
See this image and copyright information in PMC

References

    1. Bosch FX, Ribes J, Cleries R, Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9:191–211. - PubMed
    1. Yu MC, Yuan JM, Govindarajan S, Ross RK. Epidemiology of hepatocellular carcinoma. Can J Gastroenterol. 2000;14:703–9. - PubMed
    1. Beasley RP. Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer. 1988;61:1942–56. - PubMed
    1. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558–67. - PubMed
    1. Wasley A, Alter MJ. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Dis. 2000;20:1–16. - PubMed