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Review
. 2007 Dec;105(6):1805-15.
doi: 10.1213/01.ane.0000287643.13410.5e.

Pregabalin: its pharmacology and use in pain management

Noor M Gajraj  1
Affiliations
Review

Pregabalin: its pharmacology and use in pain management

Noor M Gajraj. Anesth Analg. 2007 Dec.

Erratum in

  • Anesth Analg.2008 May;106(5):1584

Abstract

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha2-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.

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