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Review
. 2007 Nov;4(4):295-302.
doi: 10.2174/156720207782446306.

"Sly as a FOXO": new paths with Forkhead signaling in the brain

Kenneth Maiese  1 , Zhao Zhong Chong, Yan Chen Shang
Affiliations
Review

"Sly as a FOXO": new paths with Forkhead signaling in the brain

Kenneth Maiese et al. Curr Neurovasc Res. 2007 Nov.

Abstract

The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus erythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.

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Figures

Fig. 1
Fig. 1. Potential cellular signaling pathways for FOXO3a
A representative illustration of possible “upstream” and “downstream” signal transduction pathways for the FOXO3a system that may be set in motion, such as during the presence of the growth factor erythropoietin (EPO).
See this image and copyright information in PMC

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