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. 2008 Feb;69(4):1043-8.
doi: 10.1016/j.phytochem.2007.10.020. Epub 2007 Nov 28.

Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia

Jianchao Chen  1 , Renrong Tian, Minghua Qiu, Lu Lu, Yongtang Zheng, Zhongquan Zhang
Affiliations

Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia

Jianchao Chen et al. Phytochemistry. 2008 Feb.

Abstract

Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3beta,7beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3beta,25-dihydroxy-5beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 microg/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50)>200 microg/ml), with a selectivity index more than 23.68 and 7.81, respectively.

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