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. 2008 Feb 15;111(4):2152-4.
doi: 10.1182/blood-2007-10-116111. Epub 2007 Nov 28.

Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells

Stefan Lob  1 , Alfred Konigsrainer, Richard Schafer, Hans-Georg Rammensee, Gerhard Opelz, Peter Terness
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Free article

Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells

Stefan Lob et al. Blood. .
Free article

Abstract

Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). Here we show that human dendritic cells (DCs) express both IDO-1 and IDO-2, but that only IDO1 mediates tryptophan catabolism; furthermore, its activity is blocked by levo-1MT, whereas D-1MT is inefficient. Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study.

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