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Review
. 2006;1(3):219-33.
doi: 10.2147/copd.2006.1.3.219.

Changing the burden of COPD mortality

David M Mannino  1 , Victor A Kiriz
Affiliations
Review

Changing the burden of COPD mortality

David M Mannino et al. Int J Chron Obstruct Pulmon Dis. 2006.

Abstract

COPD is a major cause of mortality and morbidity worldwide with an estimated 2.75 million deaths in 2000 (fourth leading cause of death). In addition to the considerable morbidity and mortality associated with COPD, this disease incurs significant healthcare and societal costs. Current COPD guidelines acknowledge that the following can improve COPD mortality: smoking cessation; long-term oxygen therapy; and lung volume reduction surgery in small subsets of COPD patients. To date, no randomized controlled trials have demonstrated an effect of pharmacological treatment on mortality, although several observational studies suggest that both long-acting bronchodilators and inhaled corticosteroids may provide a survival benefit. The possibility that these treatments reduce mortality is being investigated in ongoing large-scale clinical trials.

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Figures

Figure 1
Figure 1
Change in age-adjusted death rates for COPD and other leading causes of death in the USA from 1965 to1998. Reprinted from Pauwels RA, Rabe KF. 2004. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet, 364:613–20. Copyright © 2004 with permission from Elsevier.
Figure 2
Figure 2
Age-adjusted COPD mortality rates in individuals aged 35–74 years in selected European countries (non-European country data are provided for comparison). Reprinted from Hurd SS. 2000. International efforts directed at attacking the problem of COPD. Chest, 117:S336–8. Copyright © 2000 with permission from CHEST.
See this image and copyright information in PMC

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