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Review
. 2006;1(3):321-34.
doi: 10.2147/copd.2006.1.3.321.

Biological targets for therapeutic interventions in COPD: clinical potential

Girolamo Pelaia  1 , Alessandro Vatrella, Luca Gallelli, Teresa Renda, Mario Caputi, Rosario Maselli, Serafino A Marsico
Affiliations
Review

Biological targets for therapeutic interventions in COPD: clinical potential

Girolamo Pelaia et al. Int J Chron Obstruct Pulmon Dis. 2006.

Abstract

COPD is a widespread inflammatory respiratory disorder characterized by a progressive, poorly reversible airflow limitation. Currently available therapies are mostly based on those used to treat asthma. However, such compounds are not able to effectively reduce the gradual functional deterioration, as well as the ongoing airway and lung inflammation occurring in COPD patients. Therefore, there is an urgent need to improve the efficacy of the existing drug classes and to develop new treatments, targeting the main cellular and molecular mechanisms underlying disease pathogenesis. These therapeutic strategies will be highlighted in the present review.

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Figures

Figure 1
Figure 1
Main chemokine receptors expressed by macrophages.
Figure 2
Figure 2
Main chemokine receptors expressed by neutrophils.
Figure 3
Figure 3
Mitogen-activated protein kinases (MAPK) signalling pathways.
See this image and copyright information in PMC

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