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. 2008 Jan 4;73(1):234-40.
doi: 10.1021/jo702067z. Epub 2007 Dec 4.

A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations

Jeffrey D Butler  1 , Danielle M Solano, Lori I Robins, Makhluf J Haddadin, Mark J Kurth
Affiliations

A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations

Jeffrey D Butler et al. J Org Chem. .

Abstract

The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.

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