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Comparative Study
. 2007 Dec 5:7:143.
doi: 10.1186/1471-2334-7-143.

Incidence of human herpesvirus 8 (HHV-8) infection among HIV-uninfected individuals at high risk for sexually transmitted infections

Massimo Giuliani  1 , Paola Cordiali-Fei, Concetta Castilletti, Aldo Di Carlo, Guido Palamara, Stefano Boros, Giovanni Rezza
Affiliations
Comparative Study

Incidence of human herpesvirus 8 (HHV-8) infection among HIV-uninfected individuals at high risk for sexually transmitted infections

Massimo Giuliani et al. BMC Infect Dis. .

Abstract

Background: The occurrence of, and risk factors for, HHV-8 infection have yet to be definitively determined, particularly among heterosexual individuals with at-risk behavior for sexually transmitted infections (STI). The objective of this study was to estimate the incidence and determinants of HHV-8 infection among HIV-uninfected individuals repeatedly attending an urban STI clinic.

Methods: Sera from consecutive HIV-uninfected individuals repeatedly tested for HIV-1 antibodies were additionally tested for HHV-8 antibodies using an immunofluorescence assay. To identify determinants of HHV-8 infection, a nested case-control study and multivariate logistic regression analysis were performed.

Results: Sera from 456 HIV-uninfected individuals (224 multiple-partner heterosexuals and 232 men who have sex with men (MSM]) were identified for inclusion in the study. The HHV-8 seroprevalence at enrollment was 9.4% (21/224; 95% C.I.: 6.0-14.2%) among heterosexuals with multiple partners and 22.0% (51/232; 95% C.I.: 16.9-28.0%) among MSM. Among the 203 multiple-partner heterosexuals and 181 MSM who were initially HHV-8-negative, 17 (IR = 3.0/100 p-y, 95% C.I.: 1.9 - 4.8) and 21 (IR = 3.3/100 p-y, 95% C.I:.2.1 - 5.1) seroconversions occurred, respectively. HHV-8 seroconversion tended to be associated with a high number of sexual partners during the follow-up among MSM (> 10 partners: AOR = 3.32 95% CI:0.89-12.46) and among the multiple-partner heterosexuals (> 10 partner; AOR = 3.46, 95% CI:0.42-28.2). Moreover, among MSM, HHV-8 seroconversion tended to be associated with STI (AOR = 1.80 95%CI: 0.52-7.96). During the study period the HIV-1 incidence was lower than that of HHV-8 among both groups (0.89/100 p-y among MSM and 0.95/100 p-y among multiple-partner heterosexuals).

Conclusion: The large difference between the incidence of HHV-8 and the incidence of HIV-1 and other STIs may suggest that the circulation of HHV-8 is sustained by practices other than classical at-risk sexual behavior.

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References

    1. Challine D, Roudot-Thoraval F, Sarah T, Laperche L, Boisson B, Mauberquez S, Dubernet F, Rigot P, Lefrere F, Marcier B, Brossard Y, Rouet F, Girot R, Loiseau P, Girard D, Claquin J, Loty B, Lerable J, Mariotti M, Pawlotsky JM, Lefrere JJ. Seroprevalence of human herpes virus 8 antibody in population at high or low risk of transfusion, graft, or sexual transmission of viruses. Transfusion. 2001;41:1120–5. doi: 10.1046/j.1537-2995.2001.41091120.x. - DOI - PubMed
    1. Rezza G, Lennette ET, Giuliani M, Pezzotti P, Caprilli F, Monini P, Butto' S, Lodi G, Di Carlo A, Levy JA, Ensoli B. Prevalence and determinants of anti-lytic and anti-latent antibodes to human herpesvirus 8 among Italian individuals at risk of sexually and parenterally transmitted infections. Int J Cancer. 1998;77:361–365. doi: 10.1002/(SICI)1097-0215(19980729)77:3<361::AID-IJC9>3.0.CO;2-M. - DOI - PubMed
    1. Diamond C, Thiede H, Perdue T, MacKellar D, Valleroy LA, Corey L, The Seattle Young Men's Survey Team Seroepidemiology of human herpesvirus 8 among young men who have sex with men. Sex Transm Dis. 2001;28:176–83. doi: 10.1097/00007435-200103000-00010. - DOI - PubMed
    1. Melbye M, Cook P, Hjalgrim H, Begtrup K, Simpson GR, Biggar RJ, Ebbesen P, Schulz T. Risk Factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981–1996. Int J Cancer. 1998;77:543–548. doi: 10.1002/(SICI)1097-0215(19980812)77:4<543::AID-IJC12>3.0.CO;2-7. - DOI - PubMed
    1. Casper C, Wald A, Pauk J, Tabet SR, Corey L, Celum CL. Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men. J Infect Dis. 2002;185:990–3. doi: 10.1086/339605. - DOI - PubMed

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