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. 1976 Jun;73(6):1989-93.
doi: 10.1073/pnas.73.6.1989.

Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes

D Schubert, M Lacorbiere

Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes

D Schubert et al. Proc Natl Acad Sci U S A. 1976 Jun.

Abstract

The nicotinamide analogue 6-aminonicotinamide and dibutyryl 3':5'-cAMP inhibit myogenesis in a clonal rat cell line from skeletal muscle. Both reagents produce a similar morphological response in the cells, and stimulate collagen and glycosaminoglycan synthesis. These data suggest that 6-aminonicotinamide and dibutyryl cAMP induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes.

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