Performance of a rapid antigen test for the diagnosis of congenital malaria
- PMID: 18053347
- DOI: 10.1179/146532807X245698
Performance of a rapid antigen test for the diagnosis of congenital malaria
Abstract
Objective: To assess the performance of OptiMAL, a rapid malaria antigen capture dipstick, in diagnosing congenital malaria.
Methods: Live newborns aged 0-3 days, delivered at Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria between August 2004 and January 2005, were screened for malaria parasitaemia with an immunochromatographic test (OptiMAL) and blood film microscopy. OptiMAL detects plasmodium lactate dehydrogenase (pLDH).
Results: Twenty-one of 192 newborns (10.9%) were diagnosed with congenital malaria by blood film microscopy. The OptiMAL test was negative in all infants.
Conclusion: OptiMAL rapid malaria antigen capture dipstick might not be useful for diagnosing malaria parasitaemia in newborns. Blood film microscopy remains the gold standard for the diagnosis of congenital malaria.
Similar articles
-
Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria.J Trop Pediatr. 2008 Oct;54(5):313-20. doi: 10.1093/tropej/fmn016. Epub 2008 Mar 29. J Trop Pediatr. 2008. PMID: 18375970
-
Comparison of the OptiMAL rapid test and microscopy for detection of malaria in pregnant women in Nigeria.Trop Med Int Health. 2005 Jan;10(1):39-41. doi: 10.1111/j.1365-3156.2004.01349.x. Trop Med Int Health. 2005. PMID: 15655012
-
Rapid 'dipstick' assays for the detection of malaria.Am Fam Physician. 2000 Mar 15;61(6):1640, 1643. Am Fam Physician. 2000. PMID: 10750873 No abstract available.
-
Update on rapid diagnostic testing for malaria.Clin Microbiol Rev. 2008 Jan;21(1):97-110. doi: 10.1128/CMR.00035-07. Clin Microbiol Rev. 2008. PMID: 18202438 Free PMC article. Review.
-
Malaria diagnosis: a review.Braz J Med Biol Res. 1996 Apr;29(4):431-43. Braz J Med Biol Res. 1996. PMID: 8736105 Review.
Cited by
-
Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing.Sci Rep. 2017 May 18;7(1):2080. doi: 10.1038/s41598-017-02173-6. Sci Rep. 2017. PMID: 28522856 Free PMC article.
-
Neonatal and congenital malaria (NCM): a case series in the Tigray region, northern Ethiopia.Malar J. 2025 Jul 1;24(1):210. doi: 10.1186/s12936-025-05466-8. Malar J. 2025. PMID: 40597346 Free PMC article.
-
Diagnostic value of rapid test for malaria among febrile neonates in a tertiary hospital in North-East Nigeria: a prospective cross-sectional study.Arch Dis Child. 2023 Dec 14;109(1):11-15. doi: 10.1136/archdischild-2023-325906. Arch Dis Child. 2023. PMID: 37879855 Free PMC article.
-
Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries.Cochrane Database Syst Rev. 2011 Jul 6;2011(7):CD008122. doi: 10.1002/14651858.CD008122.pub2. Cochrane Database Syst Rev. 2011. PMID: 21735422 Free PMC article.
-
High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis.J Glob Health. 2020 Jun;10(1):010411. doi: 10.7189/jogh.10.010411. J Glob Health. 2020. PMID: 32373330 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical