Comment
doi: 10.1016/j.cmet.2007.11.005.
FoxO3 controls dangerous proteolytic liaisons
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- PMID: 18054311
- DOI: 10.1016/j.cmet.2007.11.005
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Comment
FoxO3 controls dangerous proteolytic liaisons
Cell Metab.
2007 Dec.
Free article
Abstract
FoxO3 regulates the transcription of critical components of the ubiquitin-proteasome system in muscle wasting. Two reports (Mammucari et al., 2007; Zhao et al., 2007) now implicate FoxO3 in the transcription of autophagy-related genes and provide the first direct evidence for a coordinated role of autophagy in muscle atrophy.
Comment on
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FoxO3 controls autophagy in skeletal muscle in vivo.Cell Metab. 2007 Dec;6(6):458-71. doi: 10.1016/j.cmet.2007.11.001. Cell Metab. 2007. PMID: 18054315
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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.Cell Metab. 2007 Dec;6(6):472-83. doi: 10.1016/j.cmet.2007.11.004. Cell Metab. 2007. PMID: 18054316
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