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. 2008 Jan 15;18(2):634-9.
doi: 10.1016/j.bmcl.2007.11.076. Epub 2007 Nov 28.

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA

Soong-Hoon Kim  1 , John S Tokarski, Kenneth J Leavitt, Brian E Fink, Mark E Salvati, Robert Moquin, Mary T Obermeier, George L Trainor, Gregory G Vite, Linda K Stadnick, Jonathan S Lippy, Dan You, Matthew V Lorenzi, Ping Chen
Affiliations

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA

Soong-Hoon Kim et al. Bioorg Med Chem Lett. .

Abstract

2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (e.g., 20h, TrkA IC(50)=0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations.

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