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. 2007 Dec;92(12):1711-2.
doi: 10.3324/haematol.11636.

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Anne L Morkbak  1 , Anne-Mette Hvas, Nils Milman, Ebba Nexo
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Free article

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Anne L Morkbak et al. Haematologica. 2007 Dec.
Free article

Abstract

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

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