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Meta-Analysis
. 2007 Dec;164(12):1791-802.
doi: 10.1176/appi.ajp.2007.07060906.

A meta-analysis of cognitive remediation in schizophrenia

Susan R McGurk  1 , Elizabeth W Twamley, David I Sitzer, Gregory J McHugo, Kim T Mueser
Affiliations
Meta-Analysis

A meta-analysis of cognitive remediation in schizophrenia

Susan R McGurk et al. Am J Psychiatry. 2007 Dec.

Abstract

Objective: This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia.

Method: A meta-analysis was conducted of 26 randomized, controlled trials of cognitive remediation in schizophrenia including 1,151 patients.

Results: Cognitive remediation was associated with significant improvements across all three outcomes, with a medium effect size for cognitive performance (0.41), a slightly lower effect size for psychosocial functioning (0.36), and a small effect size for symptoms (0.28). The effects of cognitive remediation on psychosocial functioning were significantly stronger in studies that provided adjunctive psychiatric rehabilitation than in those that provided cognitive remediation alone.

Conclusions: Cognitive remediation produces moderate improvements in cognitive performance and, when combined with psychiatric rehabilitation, also improves functional outcomes.

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Conflict of interest statement

All authors report no competing interests.

Figures

FIGURE 1
FIGURE 1
Effect Sizes for Overall Cognition in Randomized, Controlled Trials of Cognitive Remediation in Schizophrenia
See this image and copyright information in PMC

Comment in

References

    1. McGurk SR, Mueser KT. Cognitive functioning, symptoms, and work in supported employment: a review and heuristic model. Schizophr Res. 2004;70:147–174. - PubMed
    1. Mueser KT. Cognitive functioning, social adjustment and long-term outcome in schizophrenia. In: Sharma T, Harvey P, editors. Cognition in Schizophrenia: Impairments, Importance, and Treatment Strategies. Oxford, UK: Oxford University Press; 2000. pp. 157–177.
    1. Corrigan PW, Mueser KT, Bond GR, Drake RE, Solomon P. The Principles and Practice of Psychiatric Rehabilitation: An Empirical Approach. New York: Guilford; 2007.
    1. Smith TE, Hull JW, Romanelli S, Fertuck E, Weiss KA. Symptoms and neurocognition as rate limiters in skills training for psychotic patients. Am J Psychiatry. 1999;156:1817–1818. - PubMed
    1. Wykes T, Dunn G. Cognitive deficit and the prediction of rehabilitation success in a chronic psychiatric group. Psychol Med. 1992;22:389–398. - PubMed

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