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Comparative Study
. 2007 Dec;164(12):1890-9.
doi: 10.1176/appi.ajp.2007.05111903.

Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia

Beng-Choon Ho  1 , Nancy C Andreasen, Jeffrey D Dawson, Thomas H Wassink
Affiliations
Comparative Study

Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia

Beng-Choon Ho et al. Am J Psychiatry. 2007 Dec.

Abstract

Objective: Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations.

Method: High-resolution magnetic resonance (MR) images of the whole brain were obtained for 119 patients with recent-onset schizophrenia spectrum disorders. Changes in brain volumes over an average of 3 years were compared between brain-derived neurotrophic factor (BDNF) val66met genotype groupings. Exploratory analyses were conducted to examine relationships between antipsychotic treatment and brain volume changes as well as the effects of BDNF genotype on changes in cognition and symptoms.

Results: Significant genotype effects were observed on within-subject changes in volumes of frontal lobe gray matter, lateral ventricles, and sulcal CSF. Met allele carriers had significantly greater reductions in frontal gray matter volume, with reciprocal volume increases in the lateral ventricles and sulcal (especially frontal and temporal) CSF than Val homozygous patients. Independent of BDNF genotype, more antipsychotic exposure between MRI scans correlated with greater volume reductions in frontal gray matter, particularly among patients who were initially treatment naive. There were no statistically significant genotype effects on within-subject changes in cognition or symptoms.

Conclusions: BDNF(Met) variant may be one of several factors affecting progressive brain volume changes in schizophrenia.

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Figures

Figure 1
Figure 1
Variance in MRI brain volume changes associated with BDNF genotype status and antipsychotic treatment.
See this image and copyright information in PMC

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References

    1. Schulz SC, Koller MM, Kishore PR, Hamer RM, Gehl JJ, Friedel RO. Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. Am J Psychiatry. 1983;140(12):1592–5. - PubMed
    1. Illowsky BP, Juliano DM, Bigelow LB, Weinberger DR. Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study. J Neurol Neurosurg Psychiatry. 1988;51(2):209–13. - PMC - PubMed
    1. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res. 1997;74(3):129–40. - PubMed
    1. Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, Gur RC. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch Gen Psychiatry. 1998;55(2):145–52. - PubMed
    1. Lieberman J, Chakos M, Wu H, Alvir J, Hoffman E, Robinson D, Bilder R. Longitudinal study of brain morphology in first episode schizophrenia. Biol Psychiatry. 2001;49(6):487–99. - PubMed

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