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. 2007 Nov;56(11):1378-83.

[Prevalence of chlamydia-pneumoniae-specific immunoglobulin M antibody and acute exacerbations of asthma in childhood]

[Article in Japanese]
Satoshi Sato  1 , Hisashi Kawashima, Yasuyo Kashiwagi, Nobuhisa Ushio, Makoto Nagai, Kouji Takekuma, Akinori Hoshika
Affiliations
  • PMID: 18059151

[Prevalence of chlamydia-pneumoniae-specific immunoglobulin M antibody and acute exacerbations of asthma in childhood]

[Article in Japanese]
Satoshi Sato et al. Arerugi. 2007 Nov.

Abstract

Background: Chlamydia pneumoniae is a frequent causative agent of acute respiratory disease and has been recently reported as a possible cause of asthma. We investigated the prevalence of C. pneumoniae infections in childhood patients with acute exacerbations of asthma.

Method: One hundred twenty-six childhood patients with acute exacerbations of asthma, 77 with acute bronchitis and 22 Respiratory syncytial virus infections were studied. Serum samples were obtained and tested for C. pneumoniae-specific IgM antibody by Enzyme-Linked ImmunoSorbent Assay (ELISA).

Results: C. pneumoniae IgM-positive results were observed in 48.4% (Index value>or=1.60) and 23% (Index value>or=1.10) of patients with acute exacerbations of asthma. The prevalence of C. pneumoniae-specific IgM was significantly higher in asthma cases than in other subjects (p<0.05).

Conclusion: Our data suggest that C. pneumoniae infection may trigger acute exacerbations of childhood asthma.

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