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. 2008 Jan;40(1):23-5.
doi: 10.1038/ng.2007.48. Epub 2007 Dec 2.

Psoriasis is associated with increased beta-defensin genomic copy number

Edward J Hollox  1 , Ulrike Huffmeier, Patrick L J M Zeeuwen, Raquel Palla, Jesús Lascorz, Diana Rodijk-Olthuis, Peter C M van de Kerkhof, Heiko Traupe, Gys de Jongh, Martin den Heijer, André Reis, John A L Armour, Joost Schalkwijk
Affiliations

Psoriasis is associated with increased beta-defensin genomic copy number

Edward J Hollox et al. Nat Genet. 2008 Jan.

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

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Figures

Figure 1
Figure 1
Frequency distributions of beta-defensin genomic copy number. a) Dutch controls and Dutch psoriasis patients. b) German controls and German psoriasis patients.
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