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Comment
. 2007 Dec;8(12):1088-9; author reply 1089-90.
doi: 10.1038/sj.embor.7401118.

Drp1 phosphorylation and mitochondrial regulation

Chuang-Rung Chang, Craig Blackstone
Comment

Drp1 phosphorylation and mitochondrial regulation

Chuang-Rung Chang et al. EMBO Rep. 2007 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Sequence alignment of the Drp1 sequence surrounding the PKA phosphorylation site in the indicated species. The position of the PKA phosphorylation site in Drp1 identified by Chang & Blackstone (2007) and Cribbs & Strack (2007) is indicated by an asterisk, and the consensus sequence is shaded in yellow. The position of the Cdk1/cyclin B phosphorylation site (Taguchi et al, 2007) is indicated by an arrowhead, and the consensus sequence is shown in orange. Both the PKA and Cdk1/cyclin B phosphorylation sites are conserved in all species shown. Boundary amino-acid residues are indicated to the left. Numbering for the rat sequence is derived from Cribbs & Strack (2007). Cdk1, cyclin-dependent kinase 1; Drp1, dynamin-related protein 1; PKA, cAMP-dependent protein kinase.
See this image and copyright information in PMC

Comment on

References

    1. Chang CR, Blackstone C (2007) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282: 21583–21587 - PubMed
    1. Cribbs JT, Strack S (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8: 939–944 - PMC - PubMed
    1. Jahani-Asl A, Slack RS (2007) The phosphorylation state of Drp1 determines its cell fate. EMBO Rep 8: 912–913 - PMC - PubMed
    1. Taguchi N, Ishihara N, Jokufu A, Oka T, Mihara K (2007) Mitotic phosphorylation of dynamin-related GTPase participates in mitochondrial fission. J Biol Chem 282: 11521–11529 - PubMed
    1. Zhu P-P, Patterson A, Stadler J, Seeburg DP, Sheng M, Blackstone C (2004) Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1. J Biol Chem 279: 35967–35974 - PubMed

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