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. 1991 Nov-Dec;2(6):464-5.
doi: 10.1021/bc00012a015.

Preparation of oligonucleotide-peptide conjugates

C H Tung  1 , M J Rudolph, S Stein
Affiliations

Preparation of oligonucleotide-peptide conjugates

C H Tung et al. Bioconjug Chem. 1991 Nov-Dec.

Abstract

A procedure for preparing oligonucleotide-peptide conjugates is presented. It is based on appending a maleimide group to the oligonucleotide for selective coupling to the thiol side chain of a cysteine residue in the peptide. A convenient chromatographic purification procedure, based on Fmoc-on/Fmoc-off, is described.

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