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. 1976 Jul 2;193(4247):58-9.
doi: 10.1126/science.180596.

Ethanol-induced depletion of cerebellar guanosine 3',5' -cyclic monophosphate

J D Redos, G N Catravas, W A Hunt

Ethanol-induced depletion of cerebellar guanosine 3',5' -cyclic monophosphate

J D Redos et al. Science. .

Abstract

Single doses of ethanol a severe depletion (95 percent) of cerebellar guanosine 3',5' -cyclic monophosphate (cyclic GMP) within 1 hour after administration. The degree of this depletion is dose-dependent and is a function of the amount of ethanol in the blood. Interactions between ethanol and cyclic GMP may account for some of the intoxicating properties of ethanol.

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