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Review
. 2007 Nov-Dec;55(6):363-72.
doi: 10.1007/s00005-007-0043-5. Epub 2007 Dec 3.

Recent discoveries in the genetics of melanoma and their therapeutic implications

Amélie Marquette  1 , Martine Bagot, Armand Bensussan, Nicolas Dumaz
Affiliations
Review

Recent discoveries in the genetics of melanoma and their therapeutic implications

Amélie Marquette et al. Arch Immunol Ther Exp (Warsz). 2007 Nov-Dec.

Abstract

The incidence of cutaneous malignant melanoma, tumors arising from melanocytes, has increased markedly over the past few years in many countries. Although early melanoma is curable through surgical excision, the prognosis of advanced melanoma is very poor, this tumor being resistant to current therapies. Thus there is a need for new therapies to improve the treatment of advanced melanoma. This review provides an overview of recent discoveries in the genetics of melanoma which could offer new therapeutic opportunities.

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Figures

Figure 1
Figure 1
Description of the three signal transduction pathways which have been implicated in melanocyte proliferation, differentiation and apoptosis and in melanoma genesis. cAMP pathway (left), MAPK pathway (centre) and PI3K pathway (right).
See this image and copyright information in PMC

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