Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Dec;13(4):523-80.
doi: 10.1007/s11948-007-9043-4. Epub 2007 Dec 1.

Ethical and philosophical consideration of the dual-use dilemma in the biological sciences

Affiliations

Ethical and philosophical consideration of the dual-use dilemma in the biological sciences

Seumas Miller et al. Sci Eng Ethics. 2007 Dec.

Abstract

The dual-use dilemma arises in the context of research in the biological and other sciences as a consequence of the fact that one and the same piece of scientific research sometimes has the potential to be used for bad as well as good purposes. It is an ethical dilemma since it is about promoting good in the context of the potential for also causing harm, e.g., the promotion of health in the context of providing the wherewithal for the killing of innocents. It is an ethical dilemma for the researcher because of the potential actions of others, e.g., malevolent non-researchers who might steal dangerous biological agents, or make use of the original researcher's work. And it is a dilemma for governments concerned with the security of their citizens, as well as their health. In this article we construct a taxonomy of types of "experiments of concern" in the biological sciences, and thereby map the terrain of ethical risk. We then provide a series of analyses of the ethical problems and considerations at issue in the dual-use dilemma, including the impermissibility of certain kinds of research and possible restrictions on dissemination of research results given the risks to health and security. Finally, we explore the main available institutional responses to some of the specific ethical problems posed by the dual-use dilemma in the biological sciences.

PubMed Disclaimer

Comment in

References

Bibliography

Journal Articles (* Published dual-use research findings)
    1. Anonymous Statement on the consideration of biodefence and biosecurity. Nature. 2003;421(6925):771. doi: 10.1038/nature01479. - DOI - PubMed
    1. Atlas R. M., Reppy J. Globalizing biosecurity. Biosecurity and Bioterrorism. 2005;3(1):51–60. doi: 10.1089/bsp.2005.3.51. - DOI - PubMed
    1. Badash L. Science and social responsibility. Minerva. 2004;42:285–298. doi: 10.1023/B:MINE.0000038308.46951.ed. - DOI
    1. Balmer B. Killing without the distressing preliminaries: Scientists defence of the British biological warfare programme. Minerva. 2002;40(1):57–75. doi: 10.1023/A:1015009613250. - DOI - PubMed
    1. Barletta M., Sands A., Tucker J. B. Keeping track of anthrax: The case for a biosecurity convention. Bulletin of the Atomic Scientists. 2002;58(3):57–62.
Book Chapters
    1. Briggle A. Double effect and dual use. In: Mitcham C., editor. Encyclopedia of science, technology, & ethics. Detroit, MI: Macmillan Reference USA; 2005.
    1. King J., Strauss H. The hazards of defensive biological warfare programs. In: Wright S., editor. Preventing a biological arms race. Cambridge, MA: MIT Press; 1990.
    1. Lappe M. Ethics in biological warfare research. In: Wright S., editor. Preventing a biological arms race. Cambridge, MA: MIT Press; 1990.
    1. Marshall J. M. Known stocks of the smallpox virus should be retained for research. In: Dudley W., editor. Biological warfare: Opposing viewpoints. Farmington Hills, MI: Greenhaven Press; 2004.
    1. Reed L., Shulman S. A perilous path to security? Weighing US “Biodefense” against qualitative proliferation. In: Wright S., editor. Biological warfare and disarmament: New problems, new perspectives. Lanham, Maryland: Rowman and Littlefield; 2002.
Books
    1. Alibek K., Handelman S. Biohazard. Broadway, NY: Dell Publishing; 1999.
    1. Enemark, C. (2004). Disease security in Northeast Asia: Biological weapons and natural plagues. Strategic and Defence Studies Centre – Canberra Papers on Strategy and Defence No.156, Canberra: Australian National University.
    1. Fenner F., Henderson D. A., Arita I., Ježek Z., Ladnyi I. D. Smallpox and its eradication. Geneva: World Health Organization; 1988.
    1. Gross M. L. Bioethics and armed conflict: Moral dilemmas of medicine and war. Cambridge, MA: MIT Press; 2006.
    1. Henderson, D. A., Inglesby, T. V., & O’Toole, T. (Eds.) (2002). Bioterrorism: Guidelines for medical and public health management. USA: JAMA and Archives Journals.
National Academies Publications
    1. Committee on Advances in Technology, the Prevention of their Application to Next Generation Biowarfare Threats, National Research Council . An international perspective on advancing technologies and strategies for managing dual-use risks: Report of a workshop. Washington, DC: National Academies Press; 2005.
    1. Committee on Advances in Technology, the Prevention of their Application to Next Generation Biowarfare Threats, National Research Council . Globalization, biosecurity, and the future of the life sciences. Washington, DC: National Academies Press; 2006.
    1. Committee on Balancing Scientific Openness, National Security, National Academy of Sciences, National Academy of Engineering, Institute of Medicine . Balancing scientific openness and national security controls at the nation’s nuclear weapons laboratories. Washington, DC: National Academies Press; 2000.
    1. Committee on Genomics Databases for Bioterrorism Threat Agents, National Research Council . Seeking security: Pathogens, open access, and genome databases. Washington, DC: National Academies Press; 2004. - PubMed
    1. Committee on Research Standards, Practices to Prevent the Destructive Application of Biotechnology, National Research Council . Biotechnology research in the age of terrorism. Washington, DC: National Academies Press; 2004.
Websites
    1. ABC Radio National (4 September 2005). BioWar – Background Briefing http://www.abc.net.au/rn/talks/bbing/stories/s1450124.htm Accessed 8 September 2005.
    1. Alberts, B., Wulf, Wm. A., & Fineberg, H. (13 June 2003). Current visa restrictions interfere with US science and engineering contributions to important national needs, The National Academies http://www4.nationalacademies.org/news.nsf/isbn/s12132002?OpenDocument Accessed 10 June 2005.
    1. American Medical Association (December 2004). Guidelines to prevent malevolent use of biomedical research http://www.biosecuritycodes.org/docs/AMA%20Code.pdf Accessed 11 May 2006.
    1. BBC News (19 April 2004). Caution urged over bio research http://newsvote.bbc.co.uk/mpapps/pagetools/print/news.bbc.co.uk/2/hi/hea... Accessed 2 November 2004.
    1. Biological and Toxin Weapons Convention (10 April 1972). Convention on the prohibition of the development, production and stockpiling of bacteriological (Biological) and toxin weapons and on their destruction http://www.opbw.org/convention/documents/btwctext.pdf Accessed 11 May 2006.
Miscellaneous
    1. Altman, L. (21 May 2005). WHO moves toward allowing smallpox gene experiment, New York Times, A6.
    1. Anonymous US approves development of enhanced anthrax. Arms Control Today. 2001;31(9):26.
    1. Australian Government . Weapons of mass destruction: Australia’s role in fighting proliferation. Canberra: Commonwealth of Australia; 2005.
    1. Australian Safeguards, Non-Proliferation Office . Annual report 2004–2005. Canberra: Commonwealth of Australia; 2005.
    1. Borrie, J. (February 2005). The dual-use dilemma in life science research: The approach of the international committee of the Red Cross, United Nations Institute for Disarmament Research (UNIDIR) ‘for comment’ paper.