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. 2008 Jan 3;430(1):38-42.
doi: 10.1016/j.neulet.2007.10.017. Epub 2007 Dec 3.

What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum

Karmen K Yoder  1 , David A Kareken, Evan D Morris
Affiliations

What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum

Karmen K Yoder et al. Neurosci Lett. .

Abstract

[(11)C]Raclopride ([(11)C]RAC) is a selective dopamine D(2)/D(3) antagonist that is commonly used in positron emission tomography (PET) studies to assess both basal levels of receptor availability and changes in availability caused by alterations in striatal dopamine concentration. When designing [(11)C]RAC studies, it is important to understand what variables may affect the results. Here, we examined differences in baseline striatal [(11)C]RAC binding potential (BP(ND)) under two different "rest" conditions. Thirteen subjects received [(11)C]RAC scans. Eight subjects were aware prior to initiation of scanning that they would receive a "baseline" scan, and that no additional procedures would take place during the scan ("certain rest" group, CER). Five subjects were informed that they might or might not receive an i.v. alcohol infusion during the scan ("uncertain rest" group, UNC). This group was informed five min after scan start that they would not receive alcohol. Voxel-wise analyses of binding potential (BP(ND)) images generated for both "rest" conditions indicated that receptor availability was higher in UNC than in CER. This result was confirmed by a region-of-interest analysis, which indicated that the average BP(ND) in right and left putamen was statistically higher in UNC. There were no differences in groups with respect to age or raclopride mass dose that could account for the difference in D(2)/D(3) receptor availability. Our findings suggest that even slight differences in cognitive states between groups can have an effect on BP(ND), presumably mediated by changes in endogenous dopamine concentration.

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Figures

FIGURE 1
FIGURE 1
SPM results for contrast between striatal binding potential images; UNC > CER. CER, certain. UNC, uncertain. Statistical threshold: p < 0.005, uncorrected. Display threshold: p < 0.01. Colorbar indicates t-values for each contrast. Crosshairs indicate peak t-values within each cluster. Left: Peak voxel is in the left anterior putamen, at MNI coordinate (-20, 16, -8). Right: Peak voxel is in the right posterior putamen, at MNI coordinate (32, 2, -2).
FIGURE 2
FIGURE 2
Mean [11C]raclopride binding potential from the ROI analysis. CER, certain. UNC, uncertain. A. Mean ± SD for left and right caudate. B. Mean ± SD for left and right putamen. *Statistically different from CER, p < 0.03.
See this image and copyright information in PMC

References

    1. Alpert NM, Badgaiyan RD, Livni E, Fischman AJ. A novel method for noninvasive detection of neuromodulatory changes in specific neurotransmitter systems. Neuroimage. 2003;19:1049–60. - PubMed
    1. Andersson JL, Marcus M, Nomikos GG, Svensson TH. Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system. Naunyn Schmiedebergs Arch Pharmacol. 1994;349:236–43. - PubMed
    1. Antonini A, Leenders KL, Reist H, Thomann R, Beer HF, Locher J. Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and 11C-raclopride. Arch Neurol. 1993;50:474–80. - PubMed
    1. Christian BT, Narayanan T, Shi B, Morris ED, Mantil J, Mukherjee J. Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol. J Cereb Blood Flow Metab. 2004;24:309–22. - PubMed
    1. Costes N, Merlet I, Ostrowsky K, Faillenot I, Lavenne F, Zimmer L, Ryvlin P, Le Bars D. A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. J Nucl Med. 2005;46:1980–9. - PubMed

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