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Review
. 2008 Jan;43(1):5-10.
doi: 10.1016/j.exger.2007.10.008. Epub 2007 Dec 3.

Drosophila aging 2006/2007

Paul Shaw  1 , Karen Ocorr, Rolf Bodmer, Sean Oldham
Affiliations
Review

Drosophila aging 2006/2007

Paul Shaw et al. Exp Gerontol. 2008 Jan.

Abstract

Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.

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Figures

Figure 1
Figure 1. Sleep is disrupted in older flies
Average sleep bout duration declines with age (black), while the number of nighttime awakenings increases.
Figure 2
Figure 2. M-mode traces prepared from high speed movies of dissected flies
A 1 pixel-wide region with both edges of the heart tube is defined in a single movie frame. Same regions are electronically cut from all of the frames in the movie and aligned horizontally to produce the trace. A regular heart beat is seen in young flies (at 1 week of age; top trace). Arrhythmic heart beats are evident in old flies (at 5 weeks of age; bottom trace). For quantitative analysis, see Ocorr et al 2007a.
See this image and copyright information in PMC

References

    1. Akerstedt T, Nilsson PM. Sleep as restitution: an introduction. J. Intern. Med. 2003;254:6–12. - PubMed
    1. Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM. Reduced lifespan with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum. Mol. Genet. 2007 Sept 12; ePub ahead of print. - PubMed
    1. Belgacem YH, Martin J-R. Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. PLoS One. 2007;2(1):e187. - PMC - PubMed
    1. Burger JM, Hwangbo DS, Corby-Harris V, Promislow DE. The functional costs and benefits of dietary restriction in Drosophila. Aging Cell. 2007;6:63–71. - PubMed
    1. Bushey D, Tononi HKG, Cirelli C. Changes in lifespan in hyperkinetic short sleeping mutant flies. Sleep. 2007;30:a370.

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