[Cox regression model analysis of influence of the transitional mucosa adjacent to rectal carcinoma on anastomotic recurrence after anterior resection]

Abstract

The influence of nine clinico-pathological factors on anastomotic recurrence of rectal cancer after anterior resection was analyzed using Cox regression model. Among the nine factors, the mucin histochemical changes in mucosa at the resection margins, Dukes' stage and histological type of the cancer were of significance (P less than 0.1). The most important variable for anastomotic recurrence was mucin histochemical changes at the resection margins according to the Wald statistic value. It is suggested that the transitional mucosa adjacent to rectal carcinoma in which mucin histochemical changes take place bears great weight on the further malignant transformation after anterior resection. The biological characteristics of the transitional mucosa and clinical significance of the application of Cox regression model for prognostic analysis are discussed.