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. 2008 Jan;14(1):25-7.
doi: 10.1038/nm1698. Epub 2007 Dec 6.

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

Mansun Law  1 , Toshiaki Maruyama, Jamie Lewis, Erick Giang, Alexander W Tarr, Zania Stamataki, Pablo Gastaminza, Francis V Chisari, Ian M Jones, Robert I Fox, Jonathan K Ball, Jane A McKeating, Norman M Kneteman, Dennis R Burton
Affiliations

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

Mansun Law et al. Nat Med. 2008 Jan.

Abstract

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver-chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.

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