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. 2008 Jan;9(1):33-8.
doi: 10.1038/sj.embor.7401136. Epub 2007 Dec 7.

Mitochondrial biogenesis: is an old dog still teaching us new tricks? Meeting on the Assembly of the Mitochondrial Respiratory Chain

Rosemary A Stuart  1 , Peter Rehling
Affiliations

Mitochondrial biogenesis: is an old dog still teaching us new tricks? Meeting on the Assembly of the Mitochondrial Respiratory Chain

Rosemary A Stuart et al. EMBO Rep. 2008 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Human oxidative phosphorylation disorders. Diseases associated with defects of the respiratory chain complexes can be due to mutations in the genes of the structural subunits of the five complexes, or to the inactivation of complex specific assembly factors. The ADP/ATP carrier (AAC) mediates the transfer of nucleotides across the inner mitochondrial membrane and is therefore tightly connected to energy production through oxidative phosphorylation (OXPHOS). adPEO, autosomal dominant progressive external ophthalmoplegia.
Figure 2
Figure 2
Mechanisms of mitochondrial fission and fusion. (A) A model of the mechanism of mitochondrial fission, in which the construction of membranes is driven by the assembly of Dnm1 (represented by red spheres) onto the mitochondrial surface (left). Thin section electron microscopy analysis of yeast cells showing mitochondrial constriction intermediates (right). (B) A model for the mechanism of mitochondrial fusion. Fusion requires sequential interaction of the outer mitochondrial membrane and the inner mitochondrial membranes. Components involved in mitochondrial membrane fusion include Fzo1 and Ugo1 of the outer membrane, and Mgm1 of the inner membrane (bottom right). This figure was kindly made available by S. Hoppins and J. Nunnari (Davis, CA, USA).
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Rosemary A. Stuart
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Peter Rehling
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The FASEB Summer Research Conference on the Assembly of the Mitochondrial Respiratory Chain took place between 5 and 10 August 2007, in Tucson, Arizona, USA, and was organized by D. Winge and E. Shoubridge.
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