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Review
. 2007 Nov;23(6):370-6.
doi: 10.1007/s12264-007-0055-5.

ATP-sensitive potassium channels: novel potential roles in Parkinson's disease

Jie Zeng  1 , Gang Wang, Sheng-Di Chen
Affiliations
Review

ATP-sensitive potassium channels: novel potential roles in Parkinson's disease

Jie Zeng et al. Neurosci Bull. 2007 Nov.

Abstract
in English, Chinese

The ATP-sensitive potassium (K(ATP)) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. The aim of this review is to get insight into the novel roles of K(ATP) channels in Parkinson's disease (PD), with consideration of the specificities K(ATP) channels in the central nervous system (CNS), such as the control of neuronal excitability, action potential, mitochondrial function and neurotransmitter release.

ATP 敏感性钾通道已被证实广泛分布于血맜平滑肌、 心肌、 胰腺等组织, 发挥 着诸如血맜舒张、 心肌缺血的保护及胰岛素分泌等作用。 本综述旨在阐明ATP敏感性钾通道在帕金森病发病机制中参与调控神经元电兴奋性、 线粒体功能及神经递质释放的独特角色, 以揭示对其进行深入研究的意义及作为帕金森病治疗靶点的可能性和潜在价值。

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