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Review
. 2008 Feb;7(2):177-86.
doi: 10.1128/EC.00326-07. Epub 2007 Dec 7.

Calcineurin regulation in fungi and beyond

Jamal Stie  1 , Deborah Fox
Affiliations
Review

Calcineurin regulation in fungi and beyond

Jamal Stie et al. Eukaryot Cell. 2008 Feb.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Three-dimensional ribbon diagram of the calcineurin heterodimer. The image was generated in Swiss-PdbViewer version 3.9b1 from the protein data bank file 1TCO. The catalytic (CnA) subunit is shown in blue, the regulatory (CnB) subunit is yellow, the calcium ions are depicted as gray spheres, and the ions of the Fe2+/Zn2+ cluster are represented as magenta spheres.
FIG. 2.
FIG. 2.
Model of calcineurin regulation by Hsp90, Rcn1, and immunophilins to promote fungal pathogenesis. Calcineurin is stabilized by Hsp90 association and activated by dissociation from Hsp90 in response to stress stimulus and Ca2+/calmodulin binding. Cofactors, including Rcn1 and possibly immunophilins (FKBPs and cyclophilins), associate with calcineurin to direct activation and effector function. Rcn1 is modified by reversible phosphorylation through the actions of the kinases MAPK and GSK3 and the phosphatase activity of calcineurin. Downstream effectors, such as Crz1, are dephosphorylated by activated calcineurin, resulting in the modulation of processes necessary for fungal pathogenesis, including morphogenesis; response to ion stress, serum, and growth temperature; membrane trafficking; and cell wall integrity. Black lines represent direct regulatory events and gray lines indicate potentially indirect regulatory events in calcineurin signaling.
See this image and copyright information in PMC

References

    1. Abbasi, S., J. D. Lee, B. Su, X. Chen, J. L. Alcon, J. Yang, R. E. Kellems, and Y. Xia. 2006. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J. Biol. Chem. 2817717-7726. - PubMed
    1. Adams, B., A. Musiyenko, R. Kumar, and S. Barik. 2005. A novel class of dual-family immunophilins. J. Biol. Chem. 28024308-24314. - PMC - PubMed
    1. Anglister, J., S. Grzesiek, A. C. Wang, H. Ren, C. B. Klee, and A. Bax. 1994. 1H, 13C, 15N nuclear magnetic resonance backbone assignments and secondary structure of human calcineurin B. Biochemistry 333540-3547. - PubMed
    1. Aramburu, J., F. Garcia-Cozar, A. Raghavan, H. Okamura, A. Rao, and P. G. Hogan. 1998. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1627-637. - PubMed
    1. Aramburu, J., J. Heitman, and G. R. Crabtree. 2004. Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep. 5343-348. - PMC - PubMed