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Review
. 2007 Nov;9 Suppl 4(0 4):S537-53.
doi: 10.1080/14622200701679040.

Developing the science base for reducing tobacco harm

Dorothy K Hatsukami  1 , Anne M Joseph, Mark Lesage, Joni Jensen, Sharon E Murphy, Paul R Pentel, Michael Kotlyar, Eugene Borgida, Chap Le, Stephen S Hecht
Affiliations
Review

Developing the science base for reducing tobacco harm

Dorothy K Hatsukami et al. Nicotine Tob Res. 2007 Nov.

Abstract

The University of Minnesota Transdisciplinary Tobacco Use Research Center has been examining the multiple dimensions and the scientific evidence required to determine the feasibility of tobacco harm reduction as a means to reduce tobacco-related mortality and morbidity. Because of the complexity associated with exploring this area, an interdisciplinary approach is necessary. The research components that have been of particular focus at our center include (a) developing and validating biomarkers of tobacco-related exposure and toxicity, (b) developing animal models and designing studies with humans to assess a variety of smoking reduction approaches and potential reduced exposure products, and (c) determining individual differences in response to these interventions and products. A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future.

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Figures

Figure 1
Figure 1
Conceptual model for analyses of tobacco harm reduction. Smoker population comprises the individuals from which the population participating in reduced exposure/risk methods and products is drawn. Environmental and individuals factors influence the individuals who constitute this population. Use of products and methods, with different mechanisms of action and effect, influence proximal (e.g., exposure biomarkers) and ultimate (e.g., disease risk, cessation) outcomes. Proximal outcomes can influence ultimate outcomes. These outcomes are influenced by individual differences.
Figure 2
Figure 2
Spectrum of harm across tobacco products.
See this image and copyright information in PMC

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