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Review
. 2008 Feb;123(2):157-63.
doi: 10.1111/j.1365-2567.2007.02748.x. Epub 2007 Dec 7.

Regulatory T cells and tumour immunity - observations in mice and men

Awen Gallimore  1 , Andrew Godkin
Affiliations
Review

Regulatory T cells and tumour immunity - observations in mice and men

Awen Gallimore et al. Immunology. 2008 Feb.

Abstract

An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.

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Figures

Figure 1
Figure 1
CD4+ Foxp3+ cells in methylcholanthrene-induced tumours in mice. Frozen sections of MCA-induced tumours were stained with CD4− (green) and Foxp3− (red) specific antibodies.
Figure 2
Figure 2
Histological section prepared from a resected colonic carcinoma. The neoplastic glands can be seen advancing into the wall of the colon. As indicated by the arrow, tumour tissue appears to be invaded and destroyed by a lymphocytic infiltrate.
Figure 3
Figure 3
CD4+ Foxp3+ cells in a paraffin-embedded section of a human colon carcinoma. Tumour sections were stained with CD4− (green) and Foxp3− (red) specific antibodies.
See this image and copyright information in PMC

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