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. 2008 Jan;41(1):34-7.
doi: 10.1016/j.jcv.2007.10.025.

Human bocavirus commonly involved in multiple viral airway infections

Andreas Christensen  1 , Svein Arne Nordbø, Sidsel Krokstad, Anne Gro Wesenberg Rognlien, Henrik Døllner
Affiliations

Human bocavirus commonly involved in multiple viral airway infections

Andreas Christensen et al. J Clin Virol. 2008 Jan.

Abstract

Background: Human bocavirus (HBoV) was recently discovered in children with acute respiratory tract infections. We have included a PCR for HBoV in a study on airway infections in children.

Objectives: To study the occurrence of HBoV in Norwegian children, and to evaluate the results of a semiquantitative PCR.

Study design: During a 4-month period in the winter season 2006/2007 we collected nasopharyngeal aspirations from children who were admitted to the Department of Pediatrics. All samples were examined for 17 agents with real-time PCR.

Results: HBoV was detected in 45 of 376 samples (12%). The occurrence of HBoV was stable during the study period. Multiple viral infections were present in 78% of the samples (42% double, 20% triple and 16% quadruple infections). RS-virus, enterovirus and human metapneumovirus were the most frequently codetected agents. In samples with a high load for HBoV, significantly fewer multiple infections were found than in the other samples. Eighty-eight percent of the 25 patients with HBoV recorded as either the only or the dominating virus, and 50% of the other patients, had lower respiratory tract infection. The difference was statistically significant.

Conclusions: HBoV was frequently detected in nasopharyngeal aspirates from children with airway infections in Norway. Multiple viral infections were common among the HBoV-infected patients. Semiquantitative PCR results may be useful for interpretation of clinical relevance.

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Figures

Fig. 1
Fig. 1
Number of human bocavirus (HBoV), coronavirus OC43 (Cor OC43), influenza A-virus (Infl A) and RS-virus per week.
See this image and copyright information in PMC

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