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. 2008 Jan;100(1):63-70.
doi: 10.1042/BC20070073.

Building up the inactive X chromosome

Maria R Matarazzo  1 , Andrea Cerase, Maurizio D'Esposito
Affiliations

Building up the inactive X chromosome

Maria R Matarazzo et al. Biol Cell. 2008 Jan.

Abstract

The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.

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