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. 2007 Oct:19 Suppl 2:39-41.
doi: 10.1080/1120009x.2007.11782443.

Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns

M Testa  1 , V Fanos, V Martinelli, M Stronati, M Mussap, M Del Zompo
Affiliations

Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns

M Testa et al. J Chemother. 2007 Oct.

Abstract

A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used. AMG pharmacokinetics present a strong interindividual and intraindividual variability in neonates; in the premature neonate AMG clearance is reduced and the half-life is longer, leading to higher serum trough concentrations. Neonates may require therapeutic drug monitoring (TDM) and a "tailored" therapeutic regimen. The aim of this work is to present our personal experience wtih TDM of gentamicin in 68 newborns and to compare it with data available in the literature.

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