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Comment
. 2007 Dec 12;27(50):13579-80.
doi: 10.1523/JNEUROSCI.4821-07.2007.

Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?

Se Hoon Choi  1 , Eric Norstrom
Affiliations
Comment

Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?

Se Hoon Choi et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Moderate reduction (30%) of γ-secretase activity attenuated Aβ deposition with little or no side effects. A, Mouse models with different levels of γ-secretase activity. B, Reduction of Nct or Aph-1a expression attenuated Aβ burden in APPswe;PS1ΔE9 mice. C, Moderate reduction of γ-secretase activity in Aph-1a+/− mice did not induce skin tumors or splenomegaly.
See this image and copyright information in PMC

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References

    1. Guidos CJ. Notch signaling in lymphocyte development. Semin Immunol. 2002;14:395–404. - PubMed
    1. Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005;2:e355. - PMC - PubMed
    1. Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006;440:352–357. - PubMed
    1. Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci. 2007;27:10849–10859. - PMC - PubMed
    1. Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, Jacobs RT, Zacco A, Greenberg B, Ciaccio PJ. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci. 2004;82:341–358. - PubMed

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