Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jan 17;10(2):225-8.
doi: 10.1021/ol702598q. Epub 2007 Dec 14.

New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus

Keijiro Kito  1 , Ryuhei Ookura, Sanae Yoshida, Michio Namikoshi, Takashi Ooi, Takenori Kusumi
Affiliations

New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus

Keijiro Kito et al. Org Lett. .

Abstract

Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).

PubMed Disclaimer

MeSH terms

LinkOut - more resources