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Review
. 2007 Dec 13;2(6):365-7.
doi: 10.1016/j.chom.2007.11.004.

Alkaline phosphatase: keeping the peace at the gut epithelial surface

Shipra Vaishnava  1 , Lora V Hooper
Affiliations
Free article
Review

Alkaline phosphatase: keeping the peace at the gut epithelial surface

Shipra Vaishnava et al. Cell Host Microbe. .
Free article

Abstract

Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.

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