Comment
. 2007 Dec 14;318(5857):1722; author reply 1722.
doi: 10.1126/science.1149590.
Comment on "Tumor growth need not be driven by rare cancer stem cells"
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- PMID: 18079385
- DOI: 10.1126/science.1149590
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Comment
Comment on "Tumor growth need not be driven by rare cancer stem cells"
Science.
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Abstract
Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.
Comment on
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Tumor growth need not be driven by rare cancer stem cells.Science. 2007 Jul 20;317(5836):337. doi: 10.1126/science.1142596. Science. 2007. PMID: 17641192
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